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Longevity: The Advance of Science (Part 1, 3 Parts)

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In the 20th century, the lifespan of any 100-year period in history was the largest. However, some believe that we have reached the limits of life expectancy, while others believe that there is more.

this The oldest man died on April 30 116-only 39 days before her 117th birthday. Those who know the Inaya Cannabaro Lucas sisters cite her piety, her lifelong interest in learning and education, and even her love for football (football) is the key to her longevity.

The Brazilian nun Inah sisters were born on June 8, 1908. At that time, she was so weak that many people thought they would die.

Some advocates of life extension think she did.

Changes in life expectancy

According to the post Population and Development Review.

But life span will grow as drugs succeed in combating pandemics and contagion. The twentieth century increased the life expectancy of birth at a rate of three years every ten years. And before that, it only increased once every century.

You might think that the upward trajectory of human lifespan will continue given the rocket-like acceleration of the last century. However, life spans increased by 30 years during this period, which may have reached the limit.

University of Illinois – University of Chicago (UIC) research published in Natural aging It has been determined that the rapid extension of life in the twentieth century was due to advances in medicine.

According to the author, nonetheless, these advancements have reached their limits. Further advances in prolonging life will come from other scientific pursuits, such as the development of cell and DNA repair.

Lifespan increased

According to UIC’s research, lifespan is still in the twenty-first century, but it is much slower than the last century.

“Our analysis shows that women are unlikely to survive more than 15% and men are not likely to survive more than 15%,” said S. Jay Olshansky, lead author of the study, said S. Jay Olshansky of the School of Public Health in S. Jay Olshansky. The study determined that the average life expectancy was 85 years. Women are 88 years old and men are 82 years old.

“Our results overturn the traditional view that the natural lifespan of our species gives us somewhere ahead of us – this is the life expectancy we live today,” Olshansky said. “Instead, it’s behind us – in the range of 30 to 60 years. We have now shown that even if medical advances are happening at an alarming rate, the lifespan of modern medicine is gradually decreasing.”

But on the other hand. . .

William Mair, Harvard professor of molecular metabolism, agreed with the UIC team’s discovery. But, he warned, we should not give up other avenues to extend our lives. He calls these interesting but unproven possibilities Moon shots.

“For example, look at strategies that can transfer adult cells into stem cells. Rejuvenation techniques may one day be used to slow down cells and tissues aging, or even restore cells to a younger state.Mel said. These are high-risk advanced projects. What I care about [Nature Aging] Paper is, it will lead people to believe that these moon counts are impossible, so we should not invest in them. That would be a key mistake. ”

Disease and life span

Dr. Eric Topol disagreed. He is Scripps Research Translation Institute.

In his new book Super elderly,,,,, Topol, published earlier this month, believes that means to increase lifespan are already here.

Topol’s argument is that most deaths in older people are slowly developing disease. These diseases include cancer, cardiovascular and neurological diseases.

“Common threads are the three diseases that take a long time,” Topol told Axios. “They all have the same pathogenesis or basis, and we have new tools that we have never had before.”

According to Topol, relatively simple, inexpensive testing and AI data analysis can identify who is most at risk of these diseases. As a result, doctors will be able to detect these diseases early and develop personal prevention and treatment courses.

Another area of ​​optimism is the use of GLP-1 drugs

“We are now in a real position of power to achieve the fantasy of primary prevention,” Topol said. “Being able to prevent disease because on a personal level, you have unique information about you, and that’s the real reality.”

Two ways of aging and life span

According to Mair, Topol’s approach is not strictly longevity, but it does provide significant benefits for people who want longer.

“This approach does not increase the maximum limit of human lifespan,” Mair said.

The potential for prolonging life remains

Medicine may have reached the limit of lifespan, but science still has possibilities. These possibilities focus on cell and tissue rejuvenation. Although all options are on the table.

“There is no reason why we can’t break the upper limit of about 90 years of human lifespan,” Mel said. “Public health has not yet undermined it because that’s not the goal of public health. Can it be broken by targeting aging organisms? Very likely.”

Olshansky agreed.

“It’s a glass ceiling, not a brick wall,” Olshanski said. “There is plenty of room for improvement: to reduce risk factors, work to eliminate differences and encourage people to adopt a healthier lifestyle – all of which can make people able to be longer and healthier. We can limit gersoscience through glass health and longevity and work hard and work hard and work hard to reduce the impact of aging.”

Happy 20,000 birthday! (Don’t try to blow candles)

There is no consensus on the lifespan of humans.

Posted in Natural Communications Determine that humans are maximized at 120 to 150. We just lost the ability to fully recover after physical setbacks. Scientists call this physiological elasticity.

Other researchers believe that physiological elasticity and cell and tissue decline can be overcome. If they are right, it can take more time – 1000 years, for example. A researcher, João Pedro de Magalhães, Even thinks 20,000 years is possible.

João Pedro de Magalhães is a professor of molecular bioproduction at the Institute of Inflammation and Aging, University of Birmingham, England. Based on his research on the genome of long-lived animals, he is optimistic about extending human life.

Similar to the moon mentioned by Mair, DeMagalhães believes that technology can develop methods for reprogramming cells related to aging.

“I want to cheat death,” deMagalhães told

Part 2 of this series introduces the scientifically followed path to achieve a fundamental lifespan.

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