Science is opening up two ways to extend human life. One approach is to increase the span of human life, often referred to as fundamental longevity. Another is often called HealthSpan and tries to improve a person’s well-being because they live the highest.
In the second part of our series, we examine the science of the fundamental longevity and health scope and where it will be in the future.
The road to eternal life begins
A group of mice at the San Diego laboratory of the Salk Institute of Biology, which began the current scientific search for lifespan.
A virus was injected into the age-breeding mice that contained four genes believed to have restored senescent cells. As a result, the lifespan of mice is 30% longer than usualAccording to the paper published in December issue cell.
Juan Carlos Izpisua Belmonte, the study’s lead author, believes that the study opened the door to control aging and lifespan.
“Our research shows that aging may not have to go in one direction,” Belmont said at the time. “It is plastic and carefully regulated that aging may reverse.”
Where is science
Fast forward to today. Cell recovery is the forefront of scientific research on radical life span. Although there are other enthusiastic supporters. We introduce them below.
Life Biosciences, a Boston biotech company that works with Harvard researchers, is expected to begin the first human trial involving cell rejuvenation later this year.
These trials will test whether gene revival can be treated Nonarterial pre-ischemic optic neuropathy (naion).
The reasons for naivety are not yet known and there is no treatment. However, diabetes, hypertension and smoking are risk factors.
Injections will be used to try to repair eye cells – essentially, rewinding the clock back to when the cells are healthier without being threatened by larvae.
Is this safe?
Any new treatment will raise concerns about safety. The fundamental range of longevity and health is no different.
Some animal experiments have side effects, e.g. Teratomas or large Tumors, in rare cases, die.
Old cells can be restored or reprogrammed perfectly in a Petri dish. The process becomes so successful that one type of cell can become another type of cell. For example, stem cells can be reprogrammed into muscle cells, or skin cells can be revitalized and turned into osteocytes.
Transplanted cells have been used for many years to treat a variety of cancers, blood diseases and autoimmune diseases. Stem cells are also used to produce new blood cells after chemotherapy or radiation therapy.
The main disadvantage of fully regenerating cells is the possibility of teratoma. But, in a Follow-up experimentsThe Salk team found that the reduced treatment mice did not develop tumors. Unfortunately, they didn’t have a longer time either.
Research on big-name funds
Due to the funding of famous billionaires, such as Amazon founder Jeff Bezos, it gained a lot of coverage. PayPal co-founder Jeff Theil; Openai CEO Sam Altman. Netflix documentary introduces affluent tech tycoon and life extension investor Bryan Johnson Don’t die.
One of the most funded lifespan biotech companies is said to be Palo Alto Laboratories. It opened in 2022 with an estimated $3 billion.
Other aggressive lifespan technologies
Most radical lifespan studies focus on cell repair and recovery. In addition to the above methods, there are several other areas here.
- Senolotics It is a type of drug that removes senescent cells from the body. These cells cause the aging process because they have stopped dividing. Sometimes called “zombie cells”, senescent cells can cause inflammation and tissue damage.
- Telomeres prolongation. Our chromosomes have a protective cap called telomeres. However, these caps shrink whenever the cells divide. Eventually, the telomeres become so small that the cells cannot successfully divide.
Researchers had hoped that extending telomeres would extend the lifespan of cells. Therefore, it increases the lifespan of human beings.
on the contrary, Johns Hopkins Medical Research Published in May 2023, raising concerns about the technology. The study shows that “persons with long telomeres tend to develop a range of benign and cancerous tumors, as well as clonal hematopoiesis of age-related blood conditions.”
Increase attention to health scope
The jury is still extending its long life. Although most scientists in the field believe that for most of us today, living at the age of 100 may be beyond. Therefore, the quality of longevity has attracted a lot of attention.
Research on longevity and the health status of the elderly sometimes leapfrog. An example is the study of calorie restriction mimics. In short, this is the way for lazy people who reduce their calorie intake.
For some time, reducing daily calorie intake without sacrificing essential nutrients has been an area of interest among scientists. It also occupies pop culture. 2024 Food Insight Survey Discovers Last year, 13% of respondents tried intermittent fasting.
A study in April edition Internal Medicine Yearbook Participants who practice intermittent fasting were found to be larger than those who calculated calories.
“It surprised me and was exciting,” Victoria said. CatenacciMD, co-leader of research at the University of Colorado School of Medicine.
Intermittent fasting critic
Several other studies have shown that intermittent fasting can help lose weight and improve overall health. However, some critics have issued an alarm.
Analysis conducted at a meeting of the American Heart Association last year confirmed People who are restricted to diet for eight hours a day are at a higher risk of heart disease.
one Intermittent fasting between Q&A at Mayo Clinic Identify the difficulties in research strategies.
“The main problem is that intermittent fasting is not standardized,” the clinic said.
Some fasting calls for eating for a certain number of days and then not eating for a few days. Another strategy requires limiting eating to certain hours of the day.
Things to note. If you are interested in intermittent fasting, don’t try it without consulting a doctor.
Other HealthSpan methods
Other elements that may produce prolonged lifespan and improved health status in older people are drugs used for other purposes.
Metformin Regulations commonly used to treat diabetes. Although it is now believed to have a moderate increase in lifespan. Furthermore, it shows the ability to improve health.
Another drug that is investigating to enhance health status is Rapamycin.
This powerful drug is used in a variety of procedures including organ transplantation; Lymphomaniasis (Lin), a rare lung disease found primarily in women; Tuberous sclerosis complex (TSC), a genetic disease that causes organ tumors; even as a local treatment for skin tumors.
also, Rapamycin has been shown to potentially cope with certain effects of aging, including cognitive decline.
Like many drugs, rapamycin can have a range of side effects. These include kidney damage, increased risk of cancer and high blood pressure, high cholesterol, blood problems, and other problems.
in conclusion
Medical researchers are working to study the longevity of life and improvements in the health range. It may be a day in which pills or injections can increase life for years or even improve quality of life. Again, you might die and wait for it to happen.
As you age, there are some steps you can now take to improve your health. We’re going to look at the third and final part of this series tomorrow.
Tomorrow, the last part of our series shows that you don’t have to wait – you can start changing your health, thus extending your life.
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